Generally, the larger the pay per click search engine, the more you will have to bid to get to the top for your keywords. This is why it is worth investigating different search engines to find what it would cost to bid on your keywords and how much traffic they draw.
The largest companies in the pay per click industry are Yahoo! and Google. Google is not a pay per click search engine, but it does provide pay per click advertising in text ad boxes to the right of search results it delivers. It also delivers pay per click ads to other content sites.
To find more pay per click search engines, take a look at those listed in the box in the right column of this page.
These pay per click search engines are not as large as Overture and Google, but they are worth a look. As mentioned above, one advantage these search engines can provide is they generally have lower costs per click to rank for a keyword than the larger search engines.
In addition to the general pay per click search engines, you may also be able to find thematic search engines that serve your industry or specifically cater to your target audience.